Research

Deciphering the role of macrophages in retinal fibrosis secondary to neovascular age-related macular degeneration

Understanding the genetic basis for steroid-induced eye pressure to develop personalised medicine

The aim is to develop a genetic test that will predict how a patient will respond to steroids, which are widely used to treat a range of eye conditions.

Molecular dissection of the retina to elucidate early changes in diabetes

Novel technique is first to define how every cell type in the retina responds to diabetes

Non-antibiotic antimicrobial agents for microbial keratitis

Snake venom treatment as an alternative to antibiotics in eye infections

Therapeutic potential of new tumour suppressor, PRELP, in retinoblastoma

The aim is to examine the effect of the secreted protein PRELP on the progression of retinoblastoma.

Functional and therapeutic approaches to congenital stationary night blindness

Researchers aim to improve the molecular diagnoses for a number of eye conditions by verifying computational modelling predictions of variants of unknown significance in the calcium ion channel Cav1.4.

Image fusion in the analysis of ocular inflammatory disease

Aim is to analyse the diseased eyes of animals at known stages of uveitis, and use modern methods of computer aided image processing to develop our understanding of how to interpret changes in tissue texture and appearance.

Strategies to Prevent Vascular Damage in Phase I Retinopathy of prematurity

Researchers aim to find a therapy that will protect the vessels in the early phase.

Cell-cell junctions in retinal disease: The role of ARHGEF18/p114RhoGEF

Researchers aim to identify the molecular mechanisms by which defective p114RhoGEF leads to malfunctioning of cell-cell junctions in retinal pigment epithelial cells and photoreceptors, and how such defects lead to degeneration of these cell types.